Expression of BMP-2 and Its Significance in Colorectal Cancer ...

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Cancer Research

[Abstract]

Objective: To investigate the expression and relationship between bonemorphogenetic protein-2 (BMP-2) and the clinical/pathological parameters inpatients with colorectal cancer.Method: The expressions of BMP-2 were respectively investigated in twogroup patients with colorectal cancer (n=30) and normal colorectal mucosa (n=10) by using immunohistochemical staining.Results: The positive rates of BMP-2 cells in each group were reduced inproper sequence as normal colorectal mucosa 100?(10/10) and colorectalcancer 53.33?(16/30), There were statistical significance among two group(P?0.05); The positive rates of Smad 1 cells in each group were reduced inproper sequence as normal colorectal mucosa 100?(10/10) and colorectalcancer 50?(16/30), There were statistical significance among two group(P?0.05); There were no correlation between the positive rates of BMP-2 andSmad 1 (P?0.05); There were no correlation between the expression of BMP-2or Smad 1 and age?sex?lymph node metastases and distant metastasesrespectively in patients with colorectal cancer (P?0.05).Conclusion: BMP-2 and Smad 1 proteins are expressed in normal colorectalmucosa, the altered expressions of BMP-2 and Smad 1 maybe participated inthe developing Of colorectal cancer. The expressions of BMP-2 and Smad 1may be no association with age?sex?lymph node metastases and distantmetastases in patients with colorectal cancer.

Title: Expression of BMP-2 and Its Significance in Colorectal Cancer

Category: Cancer Science

Filename: Expression of BMP-2 and Its Significance in Colorectal Cancer.pdf

Pages: 166

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